Title: Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
Authors: Li, X
Tjwa, Marc
Van Hove, Inge
Enholm, Berndt
Neven, Elke
Paavonen, Karri
Jeltsch, Michael
Juan, Toni Diez
Sievers, Richard E
Chorianopoulos, Emmanuel
Wada, Hiromichi
Vanwildemeersch, Maarten
Noel, Agnes
Foidart, Jean-Michel
Springer, Matthew L
von Degenfeld, Georges
Dewerchin, Mieke
Blau, Helen M
Alitalo, Kari
Eriksson, Ulf
Carmeliet, Peter ×
Moons, Lieve #
Issue Date: Sep-2008
Series Title: Arteriosclerosis, Thrombosis and Vascular Biology vol:28 issue:9 pages:1614-1620
Abstract: OBJECTIVE: The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear. METHODS AND RESULTS: We studied the role of VEGF-B in various models of pathological angiogenesis using mice lacking VEGF-B (VEGF-B(-/-)) or overexpressing VEGF-B(167). After occlusion of the left coronary artery, VEGF-B deficiency impaired vessel growth in the ischemic myocardium whereas, in wild-type mice, VEGF-B(167) overexpression enhanced revascularization of the infarct and ischemic border zone. By contrast, VEGF-B deficiency did not affect vessel growth in the wounded skin, hypoxic lung, ischemic retina, or ischemic limb. Moreover, VEGF-B(167) overexpression failed to enhance vascular growth in the skin or ischemic limb. CONCLUSIONS: VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. These insights might offer novel therapeutic opportunities.
ISSN: 1079-5642
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Animal Physiology and Neurobiology Section - miscellaneous
Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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