Title: Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricle
Authors: Glavez, B. G ×
Sampaolesi, Maurilio
Barbuti, A
Crespi, A
Covarello, D
Brunelli, S
Dellavalle, A
Crippa, Stefania
Balconi, G
Cuccovillo, I
Molla, F
Staszewsky, L
Latini, R
DiFrancesco, D
Cossu, G #
Issue Date: Sep-2008
Publisher: E. Arnold
Series Title: Cell Death and Differentiation vol:15 issue:9 pages:1417-1428
Abstract: Different cardiac stem/progenitor cells have been recently identified in the post-natal heart. We describe here the identification, clonal expansion and characterization of self-renewing progenitors that differ from those previously described for high spontaneous cardiac differentiation. Unique coexpression of endothelial and pericyte markers identify these cells as cardiac mesoangioblasts and allow prospective isolation and clonal expansion from the juvenile mouse ventricle. Cardiac mesoangioblasts express many cardiac transcription factors and spontaneously differentiate into beating cardiomyocytes that assemble mature sarcomeres and express typical cardiac ion channels. Cells similarly isolated from the atrium do not spontaneously differentiate. When injected into the ventricle after coronary artery ligation, cardiac mesoangioblasts efficiently generate new myocardium in the peripheral area of the necrotic zone, as they do when grafted in the embryonic chick heart. These data identify cardiac mesoangioblasts as committed progenitors, downstream of earlier stem/progenitor cells and suitable for the cell therapy of a subset of juvenile cardiac diseases.
ISSN: 1350-9047
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Interdepartemental Stem Cell Institute (-)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Glavez - Cell Death and Differentation - 2008.pdf Published 708KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science