Title: Normalization of 14-3-3 in CJD
Authors: Schrooten, Maarten ×
De Vooght, Wouter
Weckhuysen, Sarah
Van Paesschen, Wim
Van Damme, Philip #
Issue Date: Jun-2008
Series Title: Acta Neurologica Belgica vol:108 issue:2 pages:64-66
Abstract: We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob disease (CJD), who had a positive initial 14-3-3 test but a subsequent negative test under pharmacologic suppression of the periodic epileptiform discharges on EEG. Multiple factors associated with a subsequent 14-3-3 test becoming negative are known. However none of these circumstances were applicable to our patient. This case history suggests sedative therapy in CJD may induce false negative 14-3-3 testing. This appears to be a relevant finding, since the differential diagnosis between non-convulsive status epilepticus and CJD is not always evident in the initial stage of the disease and some patients with CJD present with seizures.
ISSN: 0300-9009
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Neurology
Laboratory for Cognitive Neurology
Laboratory for Epilepsy Research
Laboratory for Neurobiology (Vesalius Research Center)
× corresponding author
# (joint) last author

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