Title: Derivative spectrophotometric determination of the triethylammonium salt of cefotaxime in presence of related compounds from the synthesis
Authors: Nuevas, L ×
González, R
Rodríguez, J C
Hoogmartens, Jos #
Issue Date: Dec-1998
Series Title: Journal of pharmaceutical and biomedical analysis vol:18 issue:4-5 pages:579-83
Abstract: Cefotaxime sodium is a broad spectrum third generation antibiotic. It is obtained by reaction of 7-aminocephalosporanic acid (7-ACA) and S-(2-benzothiazolyl)2-amino-alpha-(methoxyimino)-4-thiazoleethanethio ate. 2-Mercaptobenzothiazole is a by-product of this reaction. A derivative spectrophotometric determination of cefotaxime is proposed for its determination in a reaction mixture in the presence of the related compounds from synthesis. With this method Beer's law is obeyed over a concentration range from 0.005 to 0.080 mg ml(-1) at 276.8 nm (r = 0.9995). This technique is accurate, precise (RSD = 0.4%), and has a sensitivity of 1.2% (differences in analytical response of 0.74 microg ml(-1) could be detected). Recovery experiments of cefotaxime from reaction mixtures include 100% for all assayed concentrations. For these reasons, this technique is found valid for the intended purposes.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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