Title: Analysis of tobramycin by liquid chromatography with pulsed electrochemical detection
Authors: Szúnyog, J ×
Adams, Erwin
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Oct-2000
Series Title: Journal of pharmaceutical and biomedical analysis vol:23 issue:5 pages:891-6
Abstract: The determination of tobramycin by liquid chromatography using a column packed with poly(styrene-divinylbenzene) and pulsed electrochemical detection on a gold electrode is described. The mobile phase consisted of an aqueous solution containing 52 g/l of sodium sulfate, 1.5 g/l of sodium octanesulfonate and 50 ml/l of a 0.2 M phosphate buffer pH 3.0. The total time of analysis was not more than 30 min. The effects of the different chromatographic parameters on the separation were also investigated. When a number of commercial samples of tobramycin was analyzed using this method, nine different components were separated, five of which are of unknown identity.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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