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Title: Analysis of tablets containing aspirin, acetaminophen and ascorbic acid by high-performance liquid chromatography
Authors: Thomis, R ×
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Dec-1984
Series Title: Journal of pharmaceutical sciences vol:73 issue:12 pages:1830-3
Abstract: The high-performance liquid chromatographic method described enables the quantitation of the components and the main impurities of tablets containing aspirin, acetaminophen, and ascorbic acid. A C8 reverse-phase column was used; the mobile phase was methanol-0.2 M phosphate buffer (pH 3.5)-water (20:10:70). Results obtained for a brand of effervescent tablets, normally aged for 5 years and stressed at 37 degrees C, 50 degrees C, or in 79% relative humidity at room temperature, are reported. Salicylic acid was the main product of decomposition. Diacetyl-p-aminophenol was observed to be formed by transacetylation.
ISSN: 0022-3549
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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