Title: The alpha-L-ribo-isomers of RNA and LNA (locked nucleic acid)
Authors: Sørensen, M D ×
Kvaernø, L
Bryld, T
Håkansson, A E
Keinicke, L
Verbeure, B
Herdewijn, Piet
Wengel, Jesper #
Issue Date: 2001
Publisher: Oxford University Press
Series Title: Nucleic Acids Research issue:1 (suppl.) pages:25-26
Abstract: The phosphoramidite approach has been used for the automated synthesis of alpha-L-LNA, alpha-L-RNA, and oligomers composed of mixtures of alpha-L-LNA, alpha-L-RNA and DNA monomers. Binding studies revealed very efficient recognition of single-stranded DNA and RNA target oligonucleotide strands. alpha-L-LNAs were shown to be significantly stabilized towards 3'-exonucleolytic degradation. Duplexes formed between RNA and alpha-L-LNA induced E. coli RNase H-mediated RNA cleavage, albeit very slow, at high enzyme concentration.
ISSN: 0305-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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