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Title: Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA)
Authors: Gu, Ping ×
Schepers, Guy
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 2003
Series Title: Oligonucleotides vol:13 issue:6 pages:479-489
Abstract: Cyclohexene nucleic acids (CeNA) with a D-like configuration form very stable self-complementary duplexes and stable duplexes with RNA. An increased duplex stability with Delta T(m)/mod of +1.2 degrees C is observed. The duplex with DNA is less stable. Excellent mismatch discrimination has been observed as well for the duplex with DNA as for the duplex with RNA. The results obtained with mixed CeNA sequences warrant antisense studies with CeNA. The CeNAs of opposite chirality constitute a self-pairing system on their own, resembling L-RNA sequences.
ISSN: 1545-4576
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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