This item still needs to be validated !
ITEM METADATA RECORD
Title: Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA)
Authors: Gu, Ping ×
Schepers, Guy
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: 2003
Series Title: Oligonucleotides vol:13 issue:6 pages:479-489
Abstract: Cyclohexene nucleic acids (CeNA) with a D-like configuration form very stable self-complementary duplexes and stable duplexes with RNA. An increased duplex stability with Delta T(m)/mod of +1.2 degrees C is observed. The duplex with DNA is less stable. Excellent mismatch discrimination has been observed as well for the duplex with DNA as for the duplex with RNA. The results obtained with mixed CeNA sequences warrant antisense studies with CeNA. The CeNAs of opposite chirality constitute a self-pairing system on their own, resembling L-RNA sequences.
URI: 
ISSN: 1545-4576
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
3875.pdf Published 195KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science