Title: Importance of flow/metabolism studies in predicting late recovery of function following reperfusion in patients with acute myocardial infarction
Authors: Maes, Alex ×
Mortelmans, Luc
Nuyts, Johan
Bormans, Guy
Herregods, Marie-Christine
Bijnens, Bart
Van de Werf, Frans #
Issue Date: Jun-1997
Series Title: European heart journal vol:18 issue:6 pages:954-62
Abstract: AIMS: Positron emission tomographic imaging is known to be a reliable indicator of viable myocardium in chronic heart disease. Its value in acute myocardial infarction has not been studied extensively. METHODS AND RESULTS: Sixty-two patients receiving thrombolytic therapy were studied. Myocardial tissue flow and metabolism were measured at 5 days and 3 months. Recovery of left ventricular function was investigated with echocardiography or radionuclide ventriculography. In eight patients, normal flow was found in the infarct area at 5 days with no significant changes in flow, metabolism or function over the next 3 months. In 54 patients, impaired regional myocardial blood flow in the infarct zone was observed at 5 days. In 39 patients, there was a matching positron emission tomographic pattern, while in 15 the pattern was mismatched. None of the patients with a TIMI flow grade < 3 revealed recovery of left ventricular function. In seven out of 11 patients with TIMI 3 flow and a mismatching pattern, additional angioplasty was performed with functional improvement in six. CONCLUSIONS: Recovery of ventricular function is exclusively found in patients with a TIMI flow grade 3. Patients with a positron emission tomographic mismatching pattern reveal functional recovery only after subsequent angioplasty.
ISSN: 0195-668X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
Radiopharmaceutical Research
Cardiovascular Imaging and Dynamics
× corresponding author
# (joint) last author

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