Title: A pilot study to investigate the feasibility and cardiac effects of pegylated liposomal doxorubicin (PL-DOX) as adjuvant therapy in medically fit elderly breast cancer patients
Authors: Wildiers, Hans ×
Jurcut, Ruxandra
Ganame, Javier
Herbots, Lieven
Neven, Patrick
De Backer, Julie
Denys, Hannelore
Cocquyt, Veronique
Rademakers, Frank
Voigt, Jens-Uwe
Paridaens, Robert #
Issue Date: 2008
Publisher: CRC Press
Series Title: Critical reviews in oncology/hematology vol:67 issue:2 pages:133-8
Abstract: In this pilot study, we examined the feasibility and toxicity in 16 elderly women age >/=65 receiving six cycles of pegylated liposomal doxorubicin (PL-DOX) cyclophosphamide as adjuvant chemotherapy for breast cancer. An extensive cardiologic assessment was also performed including echocardiographic Doppler-based strain rate imaging (SRI), a promising new sensitive technique to assess cardiac function. All but one patient finished the six planned cycles without major dose reductions or delay, and with limited serious toxicity showing the feasibility of this regimen. Significant decreases in radial strain and strain rate were found after six cycles of treatment while left ventricle ejection fraction remained unchanged. SRI may be a useful tool in the follow-up of elderly patients treated with anthracyclines, allowing early initiation of preventive measures in order to prevent further irreversible cardiac damage.
ISSN: 1040-8428
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Experimental Cardiology
Gynaecological Oncology
Laboratory of Experimental Oncology
Cardiovascular Imaging and Dynamics
× corresponding author
# (joint) last author

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