Title: The prevalence of microsatellite instability in head and neck squamous cell carcinoma
Authors: De Schutter, Harlinde
Spaepen, Marijke
Van Opstal, Sofie
Vander Poorten, Vincent
Verbeken, Eric
Nuyts, Sandra # ×
Issue Date: Mar-2009
Publisher: Springer-Verlag Heidelberg
Series Title: Journal of Cancer Research and Clinical Oncology vol:135 issue:35 pages:485-490
Abstract: PURPOSE: The present study aimed to use the most definitive available techniques to resolve controversy in the literature as to the prevalence of microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC). METHODS: Eighty patients with advanced HNSCC were enrolled in the study that examined 20 microsatellite markers with automatic fragment analysis. These markers included ones derived from the NCI reference panel and ones previously reported to detect MSI in HNSCC (HNSCC panel). RESULTS: Only one of 80 tumors could be considered positive for MSI. For this case, both panels showed MSI-High (8/10 positive markers for the NCI reference panel and 6/10 positive markers for the HNSCC panel). Qualitatively, the observed MSI could be classified as Type B MSI. CONCLUSIONS: The present results indicate that MSI has a low prevalence in HNSCC.
ISSN: 0171-5216
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Radiotherapy
Translational Cell & Tissue Research
Research Group Experimental Oto-rhino-laryngology
Head and Neck Oncology (+)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
harlinde de schutter j cancer research and clinical oncology.pdfmain article Published 293KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science