Title: Intra-hepatic Mitomycin C bolus infusion in the treatment of extensive liver metastases of breast cancer
Authors: Maes, Toon ×
Wildiers, Hans
Heye, Sam
Demey, Wim
Maleux, Geert
Neven, Patrick
Van Oosterom, Allan
Paridaens, Robert #
Issue Date: Jul-2008
Publisher: M. Nijhoff
Series Title: Breast cancer research and treatment vol:110 issue:1 pages:135-42
Abstract: BACKGROUND : In the treatment of extensive liver metastasis of breast cancer (LMBC), locally administered Mitomycin C (MMC) to the liver might be an effective approach with limited toxicity. PATIENTS AND METHODS : We retrospectively reviewed the records of 30 patients with LMBC treated with intra-hepatic MMC at our institution. MMC (12 mg) was administered by transcatheter bolus infusion into the hepatic arteries every 4 weeks. Tumour response according to RECIST criteria, progression free survival (PFS), overall survival (OS) and duration of response (DR) were used to evaluate efficacy. RESULTS : There was a local response in the liver and a global response in respectively 33 and 26%. The median PFS, DR and OS were 3, 4 and 7 months, respectively. There was more benefit in patients without documented metastases outside the liver and without severe liver dysfunction. Thrombocytopenia, leucocytopenia and an allergic reaction were observed after MMC administration in 20 (67%), 12 (40%) and 4 patients (13%), respectively. CONCLUSION : Intra-hepatic MMC bolus infusion as treatment of extensive LMBC is associated with limited toxicity and has a significant response rate in the liver. Prospective investigations are required to define the place of this modality for treating patients with breast cancer liver metastases.
ISSN: 0167-6806
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
Department of Oncology - miscellaneous
Gynaecological Oncology
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science