Title: Legionella pneumophila exhibits plasminogen activator activity
Authors: Vranckx, Leen ×
De Buck, Emmy
Anné, Jozef
Lammertyn, Elke #
Issue Date: Nov-2007
Publisher: Soc general microbiology
Series Title: Microbiology vol:153 pages:3757-65
Abstract: Based on their localization at the boundary of the bacterial cell and its environment, outermembrane proteins (Omps) are important determinants for interaction of bacteria with their host cell. Therefore, they can be considered as important determinants for virulence. Looking for Legionella pneumophila Omps potentially involved in virulence, we identified a gene encoding a homologue of the plasminogen activator (Pla) of Yersinia pestis. Pla belongs to the class of omptins, a family of surface proteases/adhesins that exhibit different virulence-associated functions. In this report we describe the cloning and identification of the plasminogen activator homologue Lpa of L. pneumophila and demonstrate its outer-membrane localization. Transcriptional analysis of the Lpa region revealed expression of the gene in both exponential and stationary growth phase and showed that transcription of the lpa gene is directed by its own promoter. We also show, to our knowledge for the first time, that L. pneumophila has the capacity to convert plasminogen into plasmin by the action of the outer-membrane Lpa protein.
ISSN: 1350-0872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Bacteriology (Rega Institute)
Academic Center for General Practice
× corresponding author
# (joint) last author

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