Title: The role of protein secretion systems in the virulence of the intracellular pathogen Legionella pneumophila
Authors: De Buck, Emmy ×
Anné, Jozef
Lammertyn, Elke #
Issue Date: Dec-2007
Publisher: Soc general microbiology
Series Title: Microbiology vol:153 pages:3948-53
Abstract: Legionella pneumophila is a Gram-negative facultative intracellular pathogen, which multiplies in protozoa in its natural environment and can cause Legionnaires' disease in man, following infection of alveolar macrophages. In each of the different stages of infection of host cells, virulence proteins need to be delivered to their specific place of action and therefore must cross two barriers: the inner and the outer membrane. To date, several specialized secretion machineries for transport of proteins across the inner and outer membrane have been identified in L. pneumophila. Most of these secretion pathways have been shown to affect the virulence of this pathogen. An overview will be given of all the secretion pathways and the proteins transported by these secretion systems identified so far, with special attention paid to those that play a role in the pathogenicity of L. pneumophila.
ISSN: 1350-0872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Bacteriology (Rega Institute)
Academic Center for General Practice
× corresponding author
# (joint) last author

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