Author:

Keywords:

Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, antiviral agents, drug delivery, medicinal chemistry, nucleotides, prodrugs, ANTIRETROVIRAL ACTIVITY, NUCLEOTIDE PRODRUGS, PRONUCLEOTIDES, PHOSPHATES, DELIVERY, AZT, 3'-AZIDO-3'-DEOXYTHYMIDINE, CELLS, DNA, Animals, Cell Extracts, Chromatography, High Pressure Liquid, Diphosphates, Esterases, HIV, Hydrolysis, Molecular Structure, Nucleosides, Prodrugs, 03 Chemical Sciences, Organic Chemistry, 34 Chemical sciences

Abstract:

(Figure Presented) Going incognito: A new prodrug approach has been developed to facilitate the diffusion of highly polar polyphosphorylated nucleosides across cell membranes (see scheme). Inside the cell, the masking groups on the nucleoside diphosphate should be cleaved rapidly by enzymes to release the antiviral active cargo. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.