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Title: Comparison of the effects of simmondsin and cholecystokinin on metabolism, brown adipose tissue and the pancreas in food-restricted rats
Authors: Flo, Gerda ×
Vermaut, S
Van Boven, Maurits
Daenens, Paul
Buyse, Johan
Decuypere, Eddy
Kühn, Eduard
Cokelaere, Marnix #
Issue Date: Aug-1998
Series Title: Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme vol:30 issue:8 pages:504-8
Abstract: In this study, we investigated the analogies between the physiological effects of simmondsin, a satiety-inducing glycoside extracted from jojoba seeds, and the gastro-intestinal satiation peptide, cholecystokinin. The effects of intraperitoneal injection of the biological active CCK-octapeptide on the pancreas, interscapular brown adipose tissue, growth performance and energy metabolism in normal-fed, severely food intake-restricted (50 % of normal food intake) or moderately food intake-restricted (65 % of normal food intake) growing rats were compared to the effects of 0.25 % simmondsin mixed in the food, inducing moderate food intake reduction (65 % of normal) in rats. Cholecystokinin induced pancreatic hypertrophy. In normal fed rats, cholecystokinin had no effect on brown adipose tissue or growth, while, in severely food intake-restricted rats, it caused brown adipose tissue hypertrophy and reduced growth. In moderately food intake-restricted rats, both cholecystokinin and simmondsin induced pancreatic hypertrophy, increased brown adipose weight and metabolism and caused a slight decrease in growth. We conclude that cholecystokinin may decrease growth performance in fast growing severely food intake-restricted rats by stimulating brown adipose tissue metabolism, probably because of protein shortage induced by pancreatic hyperstimulation. Simmondsin has similar effects. These results support the hypothesis that endogenous cholecystokinin is involved in the effects of simmondsin in rats.
ISSN: 0018-5043
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Livestock-Nutrition-Quality (-)
Faculty of Medicine, Campus Kulak Kortrijk
Animal Physiology and Neurobiology Section - miscellaneous
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Toxicology and Pharmacology
× corresponding author
# (joint) last author

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