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Title: Development of a capillary electrophoretic method for the separation of diastereoisomers of a new human immunodeficiency virus protease inhibitor
Authors: Leonard, Stefanie ×
Van Schepdael, Ann
Iványi, Tímea
Lázár, István
Rosier, Jan
Vanstockem, Marc
Vermeersch, Hans
Hoogmartens, Jos #
Issue Date: Feb-2005
Series Title: Electrophoresis vol:26 issue:3 pages:627-32
Abstract: A capillary electrophoretic (CE) method was developed for the separation of diastereoisomers of a new human immunodeficiency virus (HIV) protease inhibitor TMC114. In total 16 isomers of this drug have been synthesized (eight pairs of enantiomers). We succeeded in the separation of the eight diastereoisomers, but no enantiomers could be separated. Because of the high similarity and water-insolubility of these isomers, the separation is a real challenge. Different CE modes were tried out: capillary zone electrophoresis (CZE), nonaqueous capillary electrophoresis (NACE), micellar electrokinetic capillary chromatography (MEKC), and microemulsion electrokinetic capillary chromatography (MEEKC). Only MEEKC offered resolution of these compounds.
URI: 
ISSN: 0173-0835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Practical Training, Faculty of Pharmaceutical Sciences
× corresponding author
# (joint) last author

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