Title: Metabolism of nitrogen-13 labelled ammonia in different conditions in dogs, human volunteers and transplant patients
Authors: Bormans, Guy ×
Maes, Alex
Langendries, W
Nuyts, Johan
Vrolix, M
Vanhaecke, Johan
Schiepers, C
De Roo, Michel
Mortelmans, Luc
Verbruggen, Alfons #
Issue Date: Feb-1995
Publisher: Springer-Verlag
Series Title: European Journal of Nuclear Medicine vol:22 issue:2 pages:116-21
Abstract: To investigate the rate of metabolism of nitrogen-13 labelled ammonia (13NH3) in different conditions, we have determined the relative amount of unchanged 13NH3 in the blood of dogs, volunteers and transplant patients at different times following injection. In dogs, the determinations were made under basal conditions, during adenosine administration and after coronary occlusion. The results show that adenosine administration increases the metabolic rate whereas coronary occlusion does not affect 13NH3 metabolism. For both human volunteers and transplant patients the metabolic rate of 13NH3 was assessed under basal conditions and during adenosine administration. 13NH3 metabolism proceeds faster in transplant patients than in volunteers under both conditions. Adenosine administration causes a faster 13NH3 turnover in volunteers but not in transplant patients. Application of individual metabolite correction resulted in a 16% decrease in the calculated blood flow compared to uncorrected values. A smaller difference (5%) was observed between correction with mean metabolite values and individually acquired metabolite values.
ISSN: 0340-6997
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science