Title: Pouchitis, similar to active ulcerative colitis, is associated with impaired butyrate oxidation by intestinal mucosa
Authors: De Preter, Vicky
Bulteel, Veerle
Suenaert, Peter
Geboes, Karen Paula
De Hertogh, Gert
Luypaerts, Anja
Geboes, Karel
Verbeke, Kristin ×
Rutgeerts, Paul #
Issue Date: Mar-2009
Publisher: Raven Press
Series Title: Inflammatory Bowel Diseases vol:15 issue:3 pages:335-340
Abstract: Background: Healthy colonic mucosa uses butyrate as the major energy source. In ulcerative colitis (UC) butyrate oxidation has been shown to be disturbed, but it remains unclear whether this is a primary defect. The aim of this study was to measure mucosal butyrate oxidation in UC (involved and noninvolved colon) and in pouchitis and to study the relationship with endoscopic as well as histological disease activity.Methods: Butyrate oxidation was measured in 73 UC patients, 22 pouchitis patients, and 112 controls (95 colon, 17 ileum) by incubating biopsies with 1 mM (14)C-labeled Na-butyrate and measuring the released (14)CO(2).Results: Compared with that in normal colon, butyrate oxidation was significantly impaired in endoscopically active but not in quiescent disease or uninvolved colon segments. The severity of the metabolic defect was related to histological disease activity and decreased epithelial cell height. In active pouchitis, butyrate oxidation was significantly decreased compared with that in normal ileum and excluded pouches without inflammation. The histological pouchitis score correlated significantly with butyrate oxidation.Conclusions: Active UC and pouchitis show the same inflammation-related metabolic defect. Our data suggest that the defect is a consequence of inflammation and that pouchitis is metabolically similar to active UC.(Inflamm Bowel Dis 2008).
ISSN: 1078-0998
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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