Title: A review of albumin binding in CKD
Authors: Meijers, Bj√∂rn ×
Bammens, Bert
Verbeke, Kristin
Evenepoel, Pieter #
Issue Date: May-2008
Publisher: W b saunders co-elsevier inc
Series Title: American journal of kidney diseases vol:51 issue:5 pages:839-850
Abstract: Hypoalbuminemia is associated with excess mortality in patients with kidney disease. Albumin is an important oxidant scavenger and an abundant carrier protein for numerous endogenous and exogenous compounds. Several specific binding sites for anionic, neutral, and cationic ligands were described. Overall, the extent of binding depends on the ligand and albumin concentration, albumin-binding affinity, and presence of competing ligands. Chronic kidney disease affects all these determinants. This may result in altered pharmacokinetics and increased risk of toxicity. Renal clearance of albumin-bound solutes mainly depends on tubular clearance. Dialytic clearance by means of conventional hemodialysis/hemofiltration and peritoneal dialysis is limited. Other epuration techniques combining hemodialysis with adsorption have been developed. However, the benefit of these techniques remains to be proved.
ISSN: 0272-6386
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
Laboratory of Nephrology
× corresponding author
# (joint) last author

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