Title: Base pair interactions in the minor groove of double stranded DNA
Authors: Wu, T ×
Nauwelaerts, Koen
Van Aerschot, Arthur
Froeyen, Mathy
Lescrinier, Eveline
Herdewijn, Piet #
Issue Date: Jul-2006
Series Title: Journal of Organic Chemistry vol:71 issue:15 pages:5423-5431
Abstract: [Chemical Structure: See Text] A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A-T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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