Title: New techniques for the rapid characterization of oligonucleotides by mass spectrometry
Authors: McCloskey, J A
Whitehill, A B
Rozenski, Jef
Qiu, F
Crain, P F # ×
Issue Date: 1999
Publisher: Marcel dekker inc
Series Title: Nucleosides & nucleotides vol:18 issue:6-7 pages:1549-1553
Abstract: Recent advances in combined HPLC/electrospray ionization-mass spectrometry provide effective new capabilities for the rapid characterization of oligonucleotides. Accurate mass measurements with errors < 0.3 Da, and determination of base and sugar modification and of nearest neighbor identities, can be routinely carried out on 10-100 component mixtures of RNA or DNA. These procedures are widely applicable in structural and analytical studies involving mixtures of oligonucleotides.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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