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Title: Quantitative determination of amoxicillin and its decomposition products by high-performance liquid chromatography
Authors: De Pourcq, P ×
Hoebus, J
Roets, Eugene
Hoogmartens, Jos
Vanderhaeghe, Hubert #
Issue Date: Mar-1985
Series Title: Journal of Chromatography vol:321 issue:2 pages:441-9
Abstract: Amoxicillin, amoxicilloates, amoxicillin oligomers and amoxicillin piperazine-2,5-dione are separated by reversed-phase (C8) high-performance liquid chromatography with gradient elution. Quantitative results are reported for a number of samples. Amoxicillin trihydrate samples mostly contain amoxicilloate as the main impurity. Samples of the sodium salt also contain the piperazine-2,5-dione and the dimer. Higher oligomers such as the trimer and tetramer were not present in significant amounts. Several samples were also analysed by a mercurimetric titration method.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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