ITEM METADATA RECORD
Title: Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives
Authors: Ugwoke, Michael I ×
Agu, Remigius U
Verbeke, Norbert
Kinget, Renaat #
Issue Date: Nov-2005
Series Title: Advanced drug delivery reviews vol:57 issue:11 pages:1640-65
Abstract: Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that low absorption of drugs can be countered by using absorption enhancers or increasing the drug residence time in the nasal cavity, and that some mucoadhesive polymers can serve both functions. This article reviews the background of nasal mucoadhesive drug delivery with special references to the biological and pharmaceutical considerations for nasal mucoadhesive drug administration. Applications of nasal mucoadhesives for the delivery of small organic molecules, antibiotics, proteins, vaccines and DNA are also discussed. Furthermore, new classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.
ISSN: 0169-409X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2005-Ugwoke-Nasal mucoadhesive drug delivery...-Adv Drug Del Rev.pdf Published 602KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science