Oxidative stress and metabolism at rest and during exercise in persons with Down syndrome
Flore, Patrice × Bricout, Veronique-A Van Biesen, Debbie Guinot, Michel Laporte, Francois Pepin, Jean-Louis Eberhard, Yves Favre-Juvin, Anne Wuyam, Bernard van de Vliet, Peter Faure, Patrice #
Lippincott williams & wilkins
European journal of cardiovascular prevention & rehabilitation vol:15 issue:1 pages:35-42
Background Down syndrome (DS) is a risk factor for metabolic syndrome and cardiovascular disease. The greater oxidative stress described in DS can increase this risk owing to its potential deleterious effects on insulin sensitivity. We hypothesized that metabolic syndrome or its markers, at rest and during exercise, are more pronounced in young adults with DS.