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Title: Unimanual muscle activation increases interhemispheric inhibition from the active to the resting hemisphere
Authors: Vercauteren, Katrien
Pleysier, Tine
Van Belle, Liesbet
Swinnen, Stephan
Wenderoth, Nicole # ×
Issue Date: 21-Nov-2008
Publisher: Elsevier/North-Holland
Series Title: Neuroscience Letters vol:445 issue:3 pages:209-213
Abstract: Interhemispheric inhibition (IHI) is an important mechanism to maximize the independent functioning
of each hemisphere and is most likely mediated by transcallosal fibres. IHI can be investigated by paired
pulse transcranial magnetic stimulation (TMS) whereby, in half of the trials, a test stimulus (TS) over one
hemisphere is preceded by a conditioning stimulus (CS) over the other hemisphere. Whereas various
studies have investigated IHI in rest, less is known about interhemispheric interactions during voluntary
muscle activation. Here, we investigated the influence of tonic muscle activity (5% of the maximal voluntary
contraction) in either the right wrist flexor or extensor versus rest on IHI from the active (left) to
the resting (right) hemisphere. Our main finding was that tonic activation of the right wrist flexor, led
to an increase in IHI from the active (dominant left) to the resting (non-dominant right) hemisphere as
compared to rest. A control experiment employed the same design but CS intensitywas lowered to match
MEP amplitudes of the conditioning hand between active and rest conditions. This resulted in a relative
decrease of IHI. It is hypothesized that functional regulation of IHI might prevent the occurrence of mirror
activity in the primary motor cortex (M1) of the resting hemisphere and, thus, might play an important
role in the execution of unimanual actions.
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Movement Control & Neuroplasticity Research Group
× corresponding author
# (joint) last author

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