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Title: Structure elucidation of four related substances in gramicidin with liquid chromatography/mass spectrometry
Authors: Govaerts, Cindy ×
Orwa, J
Van Schepdael, Ann
Roets, Eugene
Hoogmartens, Jos #
Issue Date: Jan-2001
Series Title: Rapid communications in mass spectrometry : RCM vol:15 issue:2 pages:128-34
Abstract: A selective reversed phase liquid chromatography/mass spectrometry (LC/MS(n)) method is described for the identification of related substances in commercial gramicidin samples. Mass spectral data are acquired on an LCQ ion trap mass spectrometer equipped with an electrospray interface operated in the positive and the negative ion mode. The LCQ is ideally suited for identification of related substances because it provides on-line LC/MS(n) capability. Compared with UV detection the main advantage of this hyphenated LC/MS(n) technique is the efficient identification of novel related substances without time-consuming isolation and purification procedures. Using this method four novel related substances were separated and identified in a commercial sample.
URI: 
ISSN: 0951-4198
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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