Title: A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies
Authors: Tytgat, Jan ×
Chandy, K G
Garcia, M L
Gutman, G A
Martin-Eauclaire, M F
van der Walt, J J
Possani, L D #
Issue Date: Nov-1999
Publisher: Elsevier Publications
Series Title: Trends in Pharmacological Sciences vol:20 issue:11 pages:444-447
Abstract: Peptidyl toxins are used extensively to determine the pharmacology of ion channels. Four families of peptides have been purified from scorpion venom. In this article, the classification of K+-channel-blocking peptides belonging to family 2 peptides and comprising 30-40 amino acids linked by three or four disulfide bridges, will be discussed. Evidence is provided for the existence of 12 molecular subfamilies, named alpha-KTx1-12, containing 49 different peptides. Because of the pharmacological divergence of these peptides, the principle of classification was based on a primary sequence alignment, combined with maximum parsimony and Neighbour-Joining analysis.
ISSN: 0165-6147
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

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