Title: Racemization of aspartic acid from human dentin in the estimation of chronological age
Authors: Yekkala, Raja ×
Meers, Carine
Van Schepdael, Ann
Hoogmartens, Jos
Lambrichts, Ivo
Willems, Guy #
Issue Date: May-2006
Series Title: Forensic science international vol:159 Suppl 1 pages:S89-94
Abstract: The estimation of chronological age in cadavers, human remains and in living human beings by various methods is discussed. These methods, which are based on the age dependent non-enzymatic changes of l-form amino acids to d-form amino acids, mainly aspartic acid, are among the most reliable and accurate methods to date. Most of these methods use gas chromatography (GC). In this review, results of aspartic acid racemization in dentin at different targets are discussed. In addition, pre-considerations and guidelines are given for the selection of dentin from teeth. A pilot project was run to evaluate the efficiency of high performance liquid chromatography (HPLC) coupled with fluorescence detection. New buffer conditions were found to obtain stable derivatives of aspartic acid enantiomers for the estimation of racemization.
ISSN: 0379-0738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Forensic Dentistry
× corresponding author
# (joint) last author

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