Title: High-throughput study of phenytoin solid dispersions: Formulation using an automated solvent casting method, dissolution testing, and scaling-up
Authors: Barillaro, Valery
Pescarmona, Paolo
Van Speybroeck, Michiel
Do Thi, Thao
Van Humbeeck, Jan
Vermant, Jan
Augustijns, Patrick
Martens, Johan
Van den Mooter, Guy # ×
Issue Date: Sep-2008
Publisher: American Chemical Society
Series Title: Journal of Combinatorial Chemistry vol:10 issue:5 pages:637-643
Abstract: A high-throughput experimentation method for studying the dissolution of phenytoin, a poorly water soluble drug, was developed and validated. Solid dispersions with 12 excipients (7 polymers and 5 surfactants) were prepared and tested. Each excipient was screened with three drug loadings: 10, 20, and 40% (w/w). Each solid dispersion was prepared in triplicate, for a total of 108 samples. The drug dissolution was studied in simulated gastric fluid without pepsin plus 1% sodium laurylsulfate. This study led to the identification of three improved formulations, exhibiting an extent of dissolution higher than 90% after both 30 and 60 min. The HTE results could be reproduced at a larger scale using a conventional solvent evaporating method, proving the reliability of the HTE protocol.
ISSN: 1520-4766
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Soft Matter, Rheology and Technology Section
Centre for Surface Chemistry and Catalysis
Drug Delivery and Disposition
Physical Metallurgy and Materials Engineering Section (-)
× corresponding author
# (joint) last author

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