ITEM METADATA RECORD
Title: Comparative evaluation of co-processed lactose and microcrystalline cellulose with their physical mixtures in the formulation of folic acid tablets
Authors: Michoel, Armand ×
Rombaut, Patrick
Verhoye, Ann #
Issue Date: Jan-2002
Series Title: Pharmaceutical development and technology vol:7 issue:1 pages:79-87
Abstract: In this study, a new co-processed filler-binder ingredient for direct compression, MicroceLac 100, was compared with three different lactoses mixed with microcrystalline cellulose. The aim was to improve a folic acid tablet formulation. Therefore, the influence of drug addition to these mixtures was studied with regard to flow and binding properties. Another part of the study was focused on the interaction and segregation behavior of the drug. MicroceLac 100 showed superior flow and binding properties. Good adhesion of folic acid to the MicroceLac 100 particles could decrease demixing and segregation. The improved characteristics of co-processed material are attributed to spray drying. Sodium stearyl fumarate was chosen as a lubricant, based on ejection force measurements. The content uniformity of the newly formulated direct compression tablets met the official requirements.
ISSN: 1083-7450
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2002-Michoel-Comparative evaluation of...-Pharm Dev Technol.pdf Published 187KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science