Title: Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides
Authors: Kozlov, I A ×
Zielinski, M
Allart, B
Kerremans, Lucien
Van Aerschot, Arthur
Busson, Roger
Herdewijn, Piet
Orgel, Leslie E #
Issue Date: Jan-2000
Publisher: VCH Verlagsgesellschaft
Series Title: Chemistry - a European Journal vol:6 issue:1 pages:151-155
Abstract: Altritol nucleic acids (ANAs) are RNA analogues with a phosphorylated D-altritol backbone. The nucleobase is attached at the 2-(S)-position of the carbohydrate moiety. We report that ANA oligomers are superior to the corresponding DNA, RNA, and HNA (hexitol nucleic acid) in supporting efficient nonenzymatic template-directed synthesis of complementary RNAs from nucleoside-5'-phosphoro-2-methyl imidazolides. Activated ANA and HNA monomers do not oligomerize efficiently on DNA, RNA, HNA, or ANA templates.
ISSN: 0947-6539
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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