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Title: Surgical correction of vesicoureteral reflux: 5-year follow-up with 99Tcm-DMSA scintigraphy
Authors: Schiepers, C ×
Mesotten, Liesbet
Proesmans, Willem
Vereecken, Raoul
Verbruggen, Alfons
De Roo, Michel #
Issue Date: Feb-2001
Publisher: Lippincott williams & wilkins
Series Title: Nuclear medicine communications vol:22 issue:2 pages:217-24
Abstract: AIM: To evaluate kidney function before and after surgical correction of vesicoureteral reflux. The long-term effect was measured with quantitative nephro-scintigraphy using 99Tcm labelled dimercaptosuccinic acid (99Tcm-DMSA). METHODS: Forty-five children with a history of urinary tract infections due to vesicoureteral reflux (VUR) were studied. VUR grade was determined with contrast voiding cystourethrography. Planar scintigraphy was performed with 99Tcm-DMSA and uptake measured as a percentage of injected dose. Kidney function was evaluated at baseline and 5 years after corrective surgery. RESULTS: Three months after surgery, persistent mild reflux was found in eight of 76 treated renal units. Kidney uptake at 5-year follow-up was unchanged in the majority of children, indicating preservation of renal function found at baseline. The split renal function showed an excellent correlation (r = 0.99) between baseline and follow-up studies (regression slope 1.01). Percentage uptake had a regression slope of 0.89 significantly different from unity (P<0.05). Empirical kidney-depth correction techniques were compared. The scintigraphic pattern worsened in six kidneys, indicative of increased scarring in a minority of children. CONCLUSION: Planar nephro-scintigraphy with 99Tcm-DMSA was well tolerated in our paediatric population, and appeared appropriate to evaluate kidney function in time. After surgical correction of VUR, the baseline function was maintained in 94% of kidneys.
URI: 
ISSN: 0143-3636
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Urology Section (-)
Radiopharmacy
Section Child - Miscellaneous (-)
× corresponding author
# (joint) last author

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