Title: Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Authors: Lahortiga, Idoya ×
De Keersmaecker, Kim
Van Vlierberghe, Pieter
Graux, Carlos
Cauwelier, Barbara
Lambert, Frederic
Mentens, Nicole
Beverloo, H Berna
Pieters, Rob
Speleman, Frank
Odero, Maria D
Bauters, Marijke
Froyen, Guido
Marynen, Peter
Vandenberghe, Peter
Wlodarska, Iwona
Meijerink, Jules P P
Cools, Jan #
Issue Date: May-2007
Publisher: Nature publishing group
Series Title: Nature genetics vol:39 issue:5 pages:593-595
Abstract: We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Molecular Genetics Section (-)
Clinical Genetics Section (-)
Human Genome Laboratory (-)
Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven Center for Cancer Biology)
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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