Title: t(3;11)(q12;p15)/NUP98-LOC348801 fusion transcript in acute myeloid leukemia
Authors: Gorello, Paolo ×
Brandimarte, Lucia
La Starza, Roberta
Pierini, Valentina
Bury, Loredana
Rosati, Roberto
Martelli, Massimo F
Vandenberghe, Peter
Wlodarska, Iwona
Mecucci, Cristina #
Issue Date: Sep-2008
Series Title: Haematologica vol:93 issue:9 pages:1398-1401
Abstract: In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fused in-frame with nucleotide 1248 (exon 2) of LOC348801. RT-PCR and cloning experiments detected two in-frame spliced NUP98-LOC348801 transcripts and the reciprocal LOC348801-NUP98. A highly specific double-color double-fusion FISH assay reliably detects NUP98-LOC348801.
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Laboratory for Genetics of Malignant Disorders
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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