Title: EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22
Authors: De Weer, An ×
Speleman, Frank
Cauwelier, Barbara
Van Roy, Nadine
Yigit, Nurten
Verhasselt, Bruno
De Moerloose, Barbara
Benoit, Yves
Noens, Lucien
Selleslag, Dominik
Lippert, Eric
Struski, Stephanie
Bastard, Christian
De Paepe, Anne
Vandenberghe, Peter
Hagemeijer-Hausman, Anne
Dastugue, Nicole
Poppe, Bruce #
Issue Date: Dec-2008
Publisher: Il Pensiero Scientifico
Series Title: Haematologica vol:93 issue:12 pages:1903-1907
Abstract: Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular characterization of the recurrent translocation t(3;17)(q26;q22) in 13 hematologic malignancies. The EVI1 gene locus was rearranged in all 13 patients and was associated with EVI1 overexpression. In 9 out of 13 patients, the 17q breakpoints clustered in a 250 kb region on band 17q22 encompassing the MSI2 (musashi homologue 2) gene. Expression analyses failed to demonstrate ectopic MSI2 expression or the presence of an MSI2/EVI1 fusion gene. In conclusion, we show for the first time that the t(3;17) is indeed a recurrent chromosomal aberration in myeloid malignancies. In keeping with findings in other recurrent 3q26 rearrangements, overexpression of the EVI1 gene appears to be the major contributor to leukemogenesis in patients with a t(3;17).
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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