Title: Prostate cancer. Maximal androgen blockade versus total androgen suppression
Authors: Dumez, Herlinde ×
Van Poppel, Hendrik
Baert, Luc
Paridaens, Robert #
Issue Date: 1997
Publisher: Acta Medica Belgica
Series Title: Acta urologica Belgica vol:65 issue:1 pages:49-54
Abstract: As long as advanced prostate cancer remains androgen-dependent, it can be treated by castration in combination with anti-androgens. When despite maximal androgen blockade (MAB), progression occurs, the anti-androgen withdrawal can result in partial remission. Otherwise corticosteroids can be used in low doses in order to suppress the androgens originating from the adrenal gland: total androgen suppression (TAS). The minimal side effects and the low cost price of this treatment are important advantages, given the fact that only few efficient cytostatic agents are actually available for hormone-escaped prostate cancer. About 30% of the patients with advanced prostate cancer that became androgen independent will show a secondary remission under low doses hydrocortisone or prednisone.
ISSN: 0001-7183
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
Urology Section (-)
× corresponding author
# (joint) last author

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