Title: Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability
Authors: Augustyns, K
Vandendriessche, F
Van Aerschot, Arthur
Busson, Roger
Urbanke, C
Herdewijn, Piet # ×
Issue Date: Sep-1992
Publisher: Oxford univ press united kingdom
Series Title: Nucleic acids research vol:20 issue:18 pages:4711-4716
Abstract: Oligonucleotides containing 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (2) and 1-(3,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (3) were synthesized on a solid support using the phosphoramidite approach. The properties of these oligonucleotides were compared with the earlier reported characteristics of oligonucleotides containing 1-(2,3-dideoxy-beta-D-erythro-hexopyranosyl) thymine (1). The order in enzymatic stability of end-substituted oligonucleotides is 3 greater than 1 much greater than 2. The hybridization properties of the modified oligonucleotides are in reverse order: 2 much greater than 1 greater than 3.
ISSN: 0305-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
1998.pdf Published 594KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science