Communications in Agricultural and Applied Biological Sciences vol:73 issue:1 pages:71-76
Salmonella is worldwide one of the most important foodborne pathogens. A major difficulty in the control of Salmonella infections is the fact that Salmonella can form multicellular structures, commonly called biofilms, on various biotic and abiotic surfaces. Within these biofilms, Salmonella is protected against a wide range of environmental influences such as antibiotics, disinfectants and the immune system (13). Therefore, the prevention or eradication of these biofilms could be an effective way to restrict the spread of Salmonella. Importantly, molecules that inhibit the biofilm formation do not necessarily kill the bacteria. In this way, the development of resistance, which is a major drawback of classical antibiotics, is less likely. As such, biofilm inhibitors are a sustainable alternative in the production of safe and healthy food.
Our quest for powerful biofilm inhibitors is based on two strategies. In the first strategy, we studied the influence of several synthetic analogues of the halogenated furanones on Salmonella biofilms. In the second strategy, we used a number of computational techniques to identify new biofilm inhibi-tors.