Title: Investigation of the labelling characteristics of 99mTc-mercaptoacetyltriglycine
Authors: Bormans, Guy ×
Cleynhens, Bernard
Adriaens, Paul
Vanbilloen, H
De Roo, Michel
Verbruggen, Alfons #
Issue Date: Apr-1995
Publisher: Pergamon Press
Series Title: International Journal of Radiation Applications and Instrumentation B, Nuclear Medicine and Biology vol:22 issue:3 pages:339-49
Abstract: S-Benzyl-, S-benzamidomethyl- and S-benzoylmercaptoacetyltriglycine were synthesized and compared in exchange labelling experiments for the preparation of 99mTc-MAG3. The rate of exchange from 99mTc-tartrate to 99mTc-MAG3 starting from the respective precursors was determined in different conditions. Labelling proceeded most rapidly starting from the S-benzoyl protected precursor but efficient labelling was also accomplished using the more stable S-benzamidomethyl- and S-benzylmercaptoacetyltriglycine. 99mTc-MAG3 was also prepared by direct labelling of unprotected mercaptoacetyltriglycine at alkaline pH. Radiochemical purity in these conditions is mainly dependent on the pH during labelling.
ISSN: 0883-2897
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
× corresponding author
# (joint) last author

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