This item still needs to be validated !
ITEM METADATA RECORD
Title: Conventionalization of germ-free rats reverses the disability of rhein anthrone to induce laxation
Authors: Nijs, G
de Witte, Peter
Geboes, Karel
Mertens, J
Eyssen, Hendrik #
Issue Date: Aug-1993
Series Title: European Journal of Pharmacology vol:239 issue:1-3 pages:241-3
Abstract: This study shows that rhein anthrone has no laxative potency in germ-free rats because after intracaecal administration of a dose of 50 mg/kg the large intestine transit exceeded 240 min. The time course of the laxative potency of rhein anthrone injected intracaecally was evaluated after peroral inoculation of germ-free rats with the caecal contents of conventional rats. Large intestine transit was measured at consecutive periods, on days 0, 1, 2, 3 and 5 after peroral inoculation. It appeared that 1 day after peroral inoculation the laxative potency of rhein anthrone was already established (large intestinal transit < 10 min) and laxation remained on the following days (days 2, 3 and 5). We concluded that rhein anthrone is inactive in germ-free rats and acquires laxative potency after peroral inoculation of germ-free rats with caecal contents of conventional rats.
ISSN: 0014-2999
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
Translational Cell & Tissue Research
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy

 




All items in Lirias are protected by copyright, with all rights reserved.

© Web of science