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Title: Lack of the effect of superoxide dismutase and catalase on Na+,K+-ATPase activity in stunned rabbit hearts
Authors: Kaplan, P ×
Matejovicova, M
Herijgers, Paul
Flameng, Willem #
Issue Date: Mar-2008
Publisher: Acad sciences czech republic, inst physiology
Series Title: Physiological research vol:57 issue:suppl II pages:S61-S66
Abstract: Reactive oxygen species (ROS) have been implicated in the mechanism of postischemic contractile dysfunction, known as myocardial stunning. In this study, we examined protective effects of antioxidant enzymes, superoxide dismutase (SOD) and catalase, against ischemia/reperfusion-induced cardiac dysfunction and inhibition of Na+,K+-ATPase Activity. Isolated Langendorff-perfused rabbit hearts were subjected to 15 min of global normothermic ischemia followed by 10 min reperfusion. The hearts treated with SOD plus catalase did not show significant recovery of left ventricular (LV) end diastolic pressure compared with untreated ischemic reperfused hearts. Treatment with antioxidants had no pretective effects on developed LV pressure or its maximal positive and negative first derivatives (+/- LVdP/dt). Myocardial stunning was accompanied by significant loss in sarcolemmal Na+,K+-ATPase activity and thiol group content. Inhibition of enzyme activity and oxidation of SH groups were not prevented by antioxidant enzymes. These results suggest that administration of SOD and catalase in perfusate do not protect significantly against cardiac dysfunction in stunned rabbit myocardium.
ISSN: 0862-8408
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Experimental Cardiac Surgery
× corresponding author
# (joint) last author

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