Title: Using mild high-pressure shock to generate bacterial ghosts of Escherichia coli
Authors: Vanlint, Dietrich
Mebhratu, Mehari Tesfazgi
Michiels, Christiaan
Aertsen, Abram # ×
Issue Date: Jun-2008
Publisher: Verlag der Zeitschrift für Naturforschung
Series Title: Zeitschrift für Naturforschung B, Chemical Sciences vol:63 issue:6 pages:765-768
Abstract: In the context of vaccine development, bacterial ghosts are inert cells that retain the capacity to activate the immune system, and that can be used as vaccine or carrier for subunit or DNA vaccines. In this study we provide evidence that increasing the copynumber of the E. coli K 12 mrr locus can render naturally occurring and virulent avian pathogenic E. coli (APEC) strains hypersensitive to high pressure. We further demonstrate that mild HP shock generates inactive bacterial ghosts from these cells that have not incurred any microscopically visible structural damage. Possible benefits of high-pressure generated bacterial ghosts as a vaccine are discussed.
ISSN: 0932-0776
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Food and Microbial Technology
× corresponding author
# (joint) last author

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