Title: Developmental pharmacology: Neonates are not just small adults..
Authors: Allegaert, Karel ×
Verbesselt, René
Naulaers, Gunnar
van den Anker, J. N
Rayyan, Maissa
Debeer, Anne
de Hoon, Jan #
Issue Date: Jan-2008
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:63 issue:1 pages:16-24
Abstract: Neonatal drug dosing needs to be based on the physiological characteristics of the newborn and the pharmacokinetic parameters of the drug. Size-related changes can in part be modelled based on allometry and relates to the observation that metabolic rate relates to weight by a kg (0.75) trend. Until adult metabolic activity has been reached, ontogeny, i.e. isoenzyme-specific maturation and maturation of renal clearance also contributes to drug metabolism, making isoenzyme-specific documentation of maturation necessary.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
Clinical Pharmacology Centre (-)
× corresponding author
# (joint) last author

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