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Title: How to use drugs for pain management: from pharmacokinetics to pharmacogenomics
Authors: Allegaert, Karel ×
van den Anker, John #
Issue Date: Oct-2008
Publisher: European Federation of Chapters of the International Association for the Study of Pain
Series Title: European Journal of Pain vol:Suppl 2 pages:25-30
Abstract: The promise of pharmacogenomics (PGx), i.e. the study of the role of inheritance in the individual variation in drug response lies in its potential to further identify the right drug and dosing regimen in every individual patient. Observations on the impact of cytochrome P450 (CYP) 2D6, the µ-opioid receptor µ 1 (OPRM1), UDP-glucuronosyl (UGT) 2B7 isoenzyme, efflux transporter P-glycoprotein (P-gp) and ATP-binding cassette B1 (ABCB1/multiple drug resistence 1 (MDR1) polymorphisms on opioid disposition are provided to illustrate the potential impact of PGx on pain management.
PGx are – however – only one group of co-variates of interindividual variability. People differ and the interindividual phenotypic variability is the final result of maturation, genomic variation and environment. Other clinical characteristics, like ontogeny (i.e. age-dependent maturation), co-morbidity (e.g. hepatic or renal dysfunction) or co-medication should be considered together with the genomic variation. Population pharmacokinetic models hereby enable researchers to simultaneously assess the independent impact of different co-variates.
ISSN: 1090-3801
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
× corresponding author
# (joint) last author

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