Title: Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery
Authors: Wei, Jiwu ×
Blum, Sabine
Unger, Marcus
Jarmy, Gergely
Lamparter, Mathias
Geishauser, Albert
Vlastos, Georgios A
Chan, Gordon
Fischer, Klaus-Dieter
Rattat, Dirk
Debatin, Klaus-Michael
Hatzopoulos, Antonis K
Beltinger, Christian #
Issue Date: May-2004
Series Title: Cancer cell vol:5 issue:5 pages:477-88
Abstract: We show that mouse embryonic endothelial progenitor cells (eEPCs) home preferentially to hypoxic lung metastases when administered intravenously. This specificity is inversely related to the degree of perfusion and vascular density in the metastasis and directly related to local levels of hypoxia and VEGF. Ex vivo expanded eEPCs that were genetically modified with a suicide gene specifically and efficiently eradicated lung metastases with scant patent blood vessels. eEPCs do not express MHC I proteins, are resistant to natural killer cell-mediated cytolysis, and can contribute to tumor vessel formation also in nonsyngeneic mice. These results indicate that eEPCs can be used in an allogeneic setting to treat hypoxic metastases that are known to be resistant to conventional therapeutic regimes.
ISSN: 1535-6108
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmaceutical Research
× corresponding author
# (joint) last author

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