Title: Devazepide reverses the anorexic effect of simmondsin in the rat
Authors: Cokelaere, M M ×
Busselen, Paul
Flo, Gerda
Daenens, Paul
Decuypere, Eddy
Kühn, Eduard
Van Boven, Maurits #
Issue Date: Dec-1995
Series Title: Journal of Endocrinology vol:147 issue:3 pages:473-7
Abstract: Simmondsin, a glycoside extracted from jojoba meal (Simmondsia chinensis), causes a reduction in food intake after oral administration. To investigate the mechanism by which simmondsin reduces food intake, fasted and free-feeding rats were given simmondsin-supplemented food and simultaneously injected with devazepide, a specific antagonist of peripheral-type cholecystokinin receptors (CCKA receptors). In free-feeding rats, supplementation of food with 0.5% simmondsin caused a reduction in food intake of +/- 40% in the period of 4 h following food presentation. Intraperitoneal injection of 100 micrograms devazepide/kg body weight prevented this effect. In rats fasted for 20 h, the food intake in the 30 min after presentation of food supplemented with 0.15% or 0.50% simmondsin was reduced in a dose-related manner; this was also inhibited by simultaneous application of devazepide. It is suggested that peripheral CCKA receptors are involved in the effect of simmondsin on food intake. However, a direct effect of simmondsin on CCKA receptors has been excluded, since simmondsin was unable to cause contraction of the guinea-pig gallbladder in vitro.
ISSN: 0022-0795
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Division of Livestock-Nutrition-Quality (-)
Animal Physiology and Neurobiology Section - miscellaneous
Toxicology and Pharmacology
× corresponding author
# (joint) last author

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