Title: Incorporation of carbocyclic (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) into DNA of herpes simplex virus-infected cells
Authors: Bernaerts, R
De Clercq, E
Balzarini, Jan
Herdewijn, Piet
Verbruggen, Alfons
Issue Date: Jan-1985
Host Document: Antiviral research vol:Suppl 1 pages:51-6
Conference: First International TNO Conference on Antiviral Research location:Rotterdam, The Netherlands date:30 April-3 May 1985
Abstract: C-IVDU, the carbocyclic analogue of IVDU [(E)-5-(2-iodovinyl)-2'-deoxyuridine], in which the sugar moiety is replaced by a cyclopentane ring, is, like its parent compound, a very potent and selective inhibitor of herpes simplex virus type 1 (HSV-1) replication. Both C-IVDU and IVDU are effectively phosphorylated by HSV-1 infected cells and incorporated into viral and cellular DNA of these cells.
ISSN: 0166-3542
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Medicinal Chemistry (Rega Institute)

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