Title: [Development of new enzyme inhibitors for the treatment of AIDS[ ]
Other Titles: Ontwikkeling van nieuwe enzyme inhibitoren voor de behandeling van AIDS
Authors: Herdewijn, Piet # ×
Issue Date: Jan-1992
Series Title: Verhandelingen - Koninklijke Academie voor Geneeskunde van België vol:54 issue:2 pages:139-153
Abstract: Two different approaches can be used to discover new lead structures for further drug design. Till now, de novo drug design, however, has not led to compounds active against HIV. The more classical approach, based on screening programmes, has led to the discovery of three different enzyme inhibitors active against HIV: transition state analogues (protease inhibitors), antimetabolites (azidothymidine and analogues as reverse transcriptase inhibitors), and TIBO and its congeners (reversible reverse transcriptase inhibitors).
ISSN: 0302-6469
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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