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Title: Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-{alpha}
Authors: Callewaert, Filip ×
Venken, Katrien
Ophoff, Jill
De Gendt, Karel
Torcasio, Antonia
van Lenthe, Harry
Van Oosterwyck, Hans
Boonen, Steven
Bouillon, Roger
Verhoeven, Guido
Vanderschueren, Dirk #
Issue Date: Jan-2009
Publisher: The Federation of American Societies for Experimental Biology
Series Title: FASEB Journal vol:23 issue:1 pages:232-240
Abstract: Osteoporosis and muscle frailty are important health problems in elderly men and may be partly related to biological androgen activity. This androgen action can be mediated directly through stimulation of the androgen receptor (AR) or indirectly through stimulation of estrogen receptor-alpha (ERalpha) following aromatization of androgens into estrogens. To assess the differential action of AR and ERalpha pathways on bone and body composition, AR-ERalpha double-knockout mice were generated and characterized. AR disruption decreased trabecular bone mass, whereas ERalpha disruption had no additional effect on the AR-dependent trabecular bone loss. In contrast, combined AR and ERalpha inactivation additionally reduced cortical bone and muscle mass compared with either AR or ERalpha disruption alone. ERalpha inactivation-in the presence or absence of AR-increased fat mass. We demonstrate that AR activation is solely responsible for the development and maintenance of male trabecular bone mass. Both AR and ERalpha activation, however, are needed to optimize the acquisition of cortical bone and muscle mass. ERalpha activation alone is sufficient for the regulation of fat mass. Our findings clearly define the relative importance of AR and ERalpha signaling on trabecular and cortical bone mass as well as body composition in male mice.-Callewaert, F., Venken, K., Ophoff, J., De Gendt, K., Torcasio, A., van Lenthe, G. H., Van Oosterwyck, H., Boonen, S., Bouillon, R., Verhoeven, G., Vanderschueren, D. Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-alpha.
ISSN: 0892-6638
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomechanics Section
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Gerontology and Geriatrics
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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